Centre of Radiation Research and Technology

FREE RADICALS IN CHEMICAL BIOLOGY
WWW Page: www.chembiorad.inct.pl
(taken from CHIMIA 9/2008)

The continuous increase in interest in free radicals associated with life sciences is motivated by the discovery of numerous processes in biology that make use of these species as key into in their mechanisms. Important links have also been found with medicine since many physiopathological conditions and aging processes are correlated with free radical formation and reactivity.
In the last decade, it became clear that for an in-depth understanding of biological processes, a molecular approach, based on chemical principles and tools, was necessary. Therefore, the discipline of chemical biology was born with the scope of creating an interface between chemistry and biology, in terms, not only of methodologies, but of language and mutual comprehension as well.
The interface between free radicals and chemical biology became valuable in view of the fact that several free radical-based processes are known from the molecular point of view, and which have allowed biomarkers as well as pharmacological and biological...

RADIATION DAMAGE IN BIOMOLECULAR SYSTEMS
ESF Programme, COST Programme, Action P9 RADAM within 6th Framework Programme (2003-2007)
with over 20 university and research institutions from nearly all European countries.

SULFUR RADICAL CHEMISTRY OF BIOLOGICAL SIGNIFICANCE: THE PROTECTIVE AND DAMAGING ROLES OF THIOL AND THIOETHER RADICALS within 5th Framework Programme (2002-2006)
Contract Number: HPRN-CT-2002-00184
Acronym: SULFRAD
www.ichtj.waw.pl/sulfrad

Objectives
At the molecular level, oxidative events – now commonly called ‘oxidative stress’ – have been linked to numerous biological and pathological conditions. Many mechanistic questions have been raised, but there is a lack of basic chemical information. In particular, where competing pathways are considered, knowledge of the rates or chemical kinetics of putative reactions is usually required but is often lacking. This Network seeks to apply sophisticated radiation-chemical and related techniques to a problem central to free radical biology: the roles of sulfur free radicals in molecular mechanisms of stress. All three major cellular targets of oxidative stress will be studied: lipids, proteins and nucleic acids. The project aims to characterize sulfur radical chemistry of biological significance and to...

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(Poland-France)